If you feel that any of our content is inaccurate or out-of-date, please contact us at: [emailprotected]. This bacteriostat is usually 0.9% benzyl alcohol. On the other hand, distilled water is rather more sterilized and contains neither organic nor organic materials. Peptides the proteins little brother can do wonders for our bodies! Okay, so this is some maths stuff that I need to explain to you before it really gets on your nerves. 2) Decide how much reconstitution liquid you want to use to convert your lyophilized peptide into an injection-ready solution, and calculate the concentration of the solution. This monograph has been modified to include the generic and brand name in many instances. It is used as a solvent or dilutant for drugs or therapeutic compounds that call for aqueous injection. (WITHOUT GRABBING YOUR FREE COPY OF THE SARMS AND PEPTIDES SECRETS MINI COURSE). Leucovorin Calcium - GlobalRPH Deshalb, im Laufe der Jahre konnten wir einen Ruf als einer der besten unabhngigen Beratern zu bauen. There have been times when sterile water has been in short supply. This would kill 2 birds with one stone as not only this will solve the storage problem but repeated refrigerating and thawing is also a possible risk factor so you avoid that too! For intravenous or intramuscular injection, prepare solution by aseptically adding not more than 2 mL of Bacteriostatic Water for Injection or Bacteriostatic Sodium Chloride Injection to the contents of one vial. Reconstitution Definition: 569 Samples | Law Insider The action you just performed triggered the security solution. When the lyophilized product does not include an excipient or other additive and only represents the active ingredient, weight variation can be employed as the means to test for dose uniformity. With our easy-to-use reconstitution calculator, you now dont have to worry about all the multiplication, division or the unit conversion and all. In case you experience any of these side effects, you should immediately stop using sterile water for injections and talk to a doctor. did you ever get an answer? Dont just shoot the water like a spray or something. However, you are not allowed to assign, transfer, or subcontract any of your rights and/or obligations under these Terms. Parenteral drug products should be inspected visually for particulate matter Bacteriostatic Water Long-term storage: For long-term storage, it is recommended to aliquot the reconstituted peptide into small volumes and freeze them at -20C or -80C. Based on 26 documents. Both substances are sterile solvents formulated for use in medical settings. Freeze-drying: Freeze-drying, also known as lyophilization, is a method that removes water from the peptide solution and allows the peptide to be stored in a stable, dry form at room temperature for an extended period. If symptoms appear, injections should be discontinued pending medical consultation [9]. Overdose & Contraindications OVERDOSE Use only as a diluent or solvent. Water is an essential constituent of all body tissues and accounts for approximately 70% of total body weight. Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page. (Isotonic saline = 0.28 osmolar.) On the other hand, TB-500, another potential peptide for quick healing is usually dosed at 7.66mg per week. Drug class: Sterile irrigating solutions. IMPORTANT Use only the accompanying diluent or Bacteriostatic Water For Injection with. Before sharing sensitive information, make sure you're on a federal government site. Both have similar uses and are sterile but have drastically different demographics and indications. Would love your thoughts, please comment. Peptide Dosing Guide. First, you want to thoroughly wash your hands with soap and water for at least 20 seconds. PDF SOLU-MEDROL (methylprednisolone sodium succinate) Label - Food and Drug Deus Medicalbelieve in completing the challenges usually faced by pharmaceutical companies in India. Do NOT reuse the same saline syringe to flush VADs before and after medication administration. This solution has no antimicrobial agents. Medically reviewed by Drugs.com. The volume of the preparation to be used for diluting or dissolving any drug for injection is dependent on the vehicle concentration, dose and route of administration as recommended by the manufacturer. Bacteriostatic water and sterile water are essentially used for the same function which is to dissolve the drugs/medications for injecting purposes. If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate countermeasures, and if possible, retrieve and save the remainder of the unused vehicle for examination. However, they do differ in their composition as the bacteriostatic water contains 0.9% benzyl alcohol as a preservative. It is only used for injections such as intravenous, intramuscular and subcutaneous. Reconstitution instructions: Reconstitute with 15.6 mL of bacteriostatic water for a total volume of 16 mL. It would ideally be either 0.3ml, 0.5ml or 1ml syringe. Bacteriostatic Water for Peptides | Learn How to Prepare Bacteriostatic New comments cannot be posted and votes cannot be cast. However, if you can get your hands on some, then congratulations, youre already ahead of the game! These are the primary similarities between bacteriostatic water and sterile water [5]: Here are the key differences between bacteriostatic water and sterile water [5]: Despite their similarities, bacteriostatic water and sterile water differ in a few key areas. Yes, distilled water can also be used to reconstitute peptides alongside the bacteriostatic and sterile water. The preservative agent (0.9% benzyl alcohol) in bacteriostatic water allows packaging in multi-dose vials that resist contamination for up to 28 days when used with sterile needles. .063 mg/mL, 3200 mL c. 1000 mg/mL, 5 mL d. 64 mg/mL b. Some drugs can interact poorly with each solvent, and they are not considered universally interchangeable in clinical contexts. Use aseptic technique for single or multiple entry and withdrawal from all containers. Benzyl alcohol, a preservative in Bacteriostatic Water for Injection, USP has been associated with toxicity in neonates. Check a preview below or click on the image to see the full document. Patients, athletes, healthcare workers and others use sterile solutions to help in medication delivery, injections, irrigation and other uses. Bacteriostatic Water belongs to a class of drugs called Sterile Irrigating Solutions. Dosage form: injection, solution Your IP: Sterilization procedures should parallel that of an autoclave and a typical system should include: Provisions for sterilizing the shelf support rods unless they are only exposed to the inside of the chamber after stoppering. 1. : the action of reconstituting or state of being reconstituted. [See USP Controlled Room Temperature. In these Website Standard Terms and Conditions, Your Content shall mean any audio, video text, images or other material you choose to display on this Website. Administration of an estimated 9 mL to a 6 kg infant or neonate is potentially capable of producing blood pressure changes. Bacteriostatic Water vs reconstitution solution whats the difference? Once you open the seal of the sterile water vial, you will either have to use it preferably within the next 4 hours or discard it. If the peptide still doesnt get dissolved, perform trial and error and use various other solvents. But, for long-term storage of the powder form, the required temperature is less than -20 degrees celsius. Sample 1 Sample 2 Sample 3. We partner major pharmaceutical companies in India & abroad as a reliable and efficient contract manufacturer. Nothing really. Reddit and its partners use cookies and similar technologies to provide you with a better experience. Although both of these types of water are sterile, the difference between bacteriostatic water and sterile water is that other sterile waters for injection do not contain a bacteriostatic agent. Due to the bacteriostat, bacteriostatic water comes in a multi-dose formulation for multiple uses. Haven't had any problems with this bacteriostatic water. So, if you want to maximize the efficacy of your peptides, follow our guide step-by-step, and soon youll be a reconstitution pro. So, if you are someone who has seen the vials of both types of water, I am sure you can now understand why a bacteriostatic water vial contains considerable volume while a sterile water vial contains just a few milliliters. It also is prepared with a bacteriostat, a compound used to prevent any bacterial growth. Because most peptides are sold in powder form, one needs to dissolve/dilute them before really using them. An official website of the United States government, : That being said, using any old water to reconstitute it is a big no-no. Bacteriostatic water is water with benzyl alcohol. If you have an allergy to benzyl alcohol, discontinue or avoid bacteriostatic water and opt for sterile water. You will learn its various applications, how it differs from sterile water, and your best online source to buy bacteriostatic water kits. The Bacteriostatic Water can be used in diluting drugs that can subsequently be administered by intravenous, . A generally recognized acceptable method of sterilizing the lyophilizer is through the use of moist steam under pressure. Made with Muscle. corrective measures. Immediately you can gauge which is appropriate based on allergies. For example, the recommended dosage of BPC-157 is 1mcg to 10mcg per kg of body weight which accounts for 200mcg to 1000mcg per injection. 4 people found this helpful. It is supplied in a multiple-dose container from which repeated withdrawals may be made to dilute or dissolve drugs for injection. If I have a 2mg bottle how much water total do I put into the vial? Dont waste time and energy attempting to source syringes, alcohol swabs, and bacteriostatic water from multiple retailers. Peptides.org makes no claims that any products referenced can cure, treat or prevent any conditions, including any conditions referenced on its website or in print materials. For the 5mg vial of BPC 157, you will have to use 1ml of bacteriostatic water. The re-use of sterile water for injections is strictly prohibited. This website is using a security service to protect itself from online attacks. Bacteriostatic Water (bacteriostatic water (bacteriostatic water for injection) for injection) for Injection, USP containing additives should be given to a pregnant woman only if clearly needed. Intravenous administration of Bacteriostatic Water for Injection without a solute may result in hemolysis. Reconstitution Solution versus Bacteriostatic Water I need to rehydrate some BPC, but when I look for bacteriostatic water on Amazon, it takes me directly to "reconstitution solution." If both items are the same (benzyl alcohol bacteriostatic solutions) why use the different name? Its preservative content keeps it sterile to prevent infection, and its chemical properties allow it to efficiently dissolve solutes without compromising their integrity. pose a threat of fluid overload except possibly in very small infants. This bacteriostat is usually 0.9% benzyl alcohol. Those are bacteriostatic and sterile water. Data are unavailable on the toxicity of other preservatives in this age group. A mainstay in medical facilities, research labs, and beyond, bacteriostatic water resists contamination for up to 28 days after initial use. Their pH levels and chemistry are distinct. Good practice and a good quality assurance program would include the frequent monitoring of the volume of fill such as every 15 minutes. Where water is required for preparing or diluting medications for use in neonates, only preservative-free Sterile Water for Injection should be used. Bacteriostatic Water is available generically and has the same name. and our The container requires no vapor barrier to maintain the proper labeled volume. Its preservative content reduces the risk of contamination and infection, boosts shelf life, and enables optimal solvency for aqueous injection [6]. That means, they are single-dose vials and should be discarded after a single-use. Bacteriostatic Water for Injection Prescribing Information. Consult with pharmacist, if available. 420 Throckmorton Street, Suite 200, Fort Worth Texas 76102, Copyright 2022 BacteriostaticWater.com - All Rights Reserved, Wholesale Hospira Bacteriostatic Water Supplier, Need help? Lets just assume that you have been prescribed 500mcg of BPC 157. See PRECAUTIONS. Two sterile solutions that are commonly used are bacteriostatic water and sterile water. But dont worry, were here to help you navigate this tricky process. Once you have received the verification code, you will be able to choose a new password for your account. Consult the manufacturer's instructions for choice of vehicle, appropriate dilution or volume for dissolving the drugs to be injected, including the route and rate of injection. However, some of the other dosage forms that are lyophilized, such as hydrocortisone sodium succinate and methylprednisolone sodium succinate have no antibacterial effect when in solution. In closing, bacteriostatic water is often the preferred choice for injections in a range of contexts. With patients having the autonomy to take medications at home at their own comfort, the education on these sterile solutions is crucial. Other than the content you own, under these Terms, Buckle LLC and/or its licensors own all the intellectual property rights and materials contained in this Website. Should I dilute with sterile water (USP grade) or BW? We strive to never have a piece of inaccurate information on this website. Although, a small percentage of people report inflammation at the injection site if sterile water is used to dilute peptides that are to be injected intramuscularly. Specialists generally consider bacteriostatic water to be a more efficient solvent or dilutant. Water for Injection, USP is chemically designated H2O. Bacteriostatic Water vs. Sterile Water: The Differences That Can Save It would seem very difficult for a manufacturer to be able to demonstrate satisfactory validation of sterilization of a lyophilizer by chemical "treatment.". For those of you thinking about the volume of water, 1ml is usually enough for all the peptides available in the market. 5.0 out of 5 stars Good product. HCG solutions are to be refrigerated to prevent degradation [19]. You may be surprised to learn that they are not interchangeable [5]. Injection of HGH is considered safe when prescribed by a doctor. If any provision of these Terms is found to be invalid under any applicable law, such provisions shall be deleted without affecting the remaining provisions herein. However, research is not considered conclusive. Typically available as lyophilized powders to maintain purity and integrity, peptides require reconstitution before injection [12]. Bacteriostatic water works well as a peptide solvent, reconstituting the compounds without compromising their effectiveness. There are not many side effects associated with using bacteriostatic water. Daptomycin RF has a longer in-use shelf period although times vary based on dosage form (vial, IV bag, or syringe) and diluent used. Both act as dilutants or solvents of substances to enable injection. Your access to Peptides.org is subject to our full disclaimer and terms of use. A major concern with the filling operation is assurance of fill volumes. As the title suggestswhats the difference between bacteriostatic water and reconstitution solution? If you are a peptide researcher or laboratory professional, you can safely enjoy the benefits of bacteriostatic water with proper use. Before really using the peptide, you will have to add liquid to the powder and MIX it well to make it a solution but it isnt as simple as it sounds! Another difference is indications. Selective Estrogen Receptor Modulator (SERM), Induction of Ovulation with CLOMIMED 50 (Clomiphene Citrate), Anemia in Cancer Patients: treatment with DECAMED 250 (Nandrolone Decanoate), PROVIMED 25 (Mesterolone) for the Treatment of Male Infertility. Bacteriostatic Water for Injection, USP is a sterile, nonpyrogenic preparation of water for injection containing 0.9% (9 mg/mL) or 1.1% (11 mg/mL) benzyl alcohol added as a bacteriostatic preservative. Bacteriostatic 0.9% Sodium Chloride Injection, USP is a sterile, nonpyrogenic, isotonic solution of sodium chloride in water for injection. 1) Determine the quantity of peptide, in micrograms (mcg), in your vial. Peptide Reconstitution: Dosing, Mixing and Storage Guidelines Buckle LLC reserves the right to remove any of Your Content from this Website at any time without notice. In order to reconstitute 10 equal dosages, we need to mix 1ml of bacteriostatic water in all the 10 injections, which means 0.1ml of water per dosage. Then you're in luck! Some of the older lyophilizers cannot tolerate steam under pressure and sterilization is marginal at best. Data are unavailable on the toxicity of other preservatives in this age group. To answer this question, let's look at an example of Dr. Smith, a pharmaceutical scientist who needs to prepare a peptide solution for a clinical trial. The volume of the preparation to be used for diluting or dissolving any drug for injection is dependent on the vehicle concentration, dose and route of administration as recommended by the manufacturer. What is the difference between bacteriostatic water and sterile water Air oxidation is yet another threat to the efficacy of the peptide, especially some peptides having amino acids such as free cysteine and tryptophan. Cloudflare Ray ID: 7c0dd62a4baa8226 Gather the following: alcohol swabs, bacteriostatic water, peptide powder, and a sterile syringe. Bacteriostatic Water vs "reconstitution solution" what's - Reddit
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